One of those things I really must find the time to learn about is ClamAV, which is Open Source anti-virus software for UNIX and UNIX-like platforms (i.e. Linux & BSD). There's no file cleaning, but there is real-time scanning and reporting as well as a host of plugins, including one for mail servers.
What's more, there is now the ClamWin Windows port, and (even better) the ClamXav port for OS X.
What's more, there is now the ClamWin Windows port, and (even better) the ClamXav port for OS X.